| Title : Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease - Yerdelen_2015_Bioorg.Med.Chem.Lett_25_5576 |
| Author(s) : Yerdelen KO , Koca M , Anil B , Sevindik H , Kasap Z , Halici Z , Turkaydin K , Gunesacar G |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :5576 , 2015 |
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Abstract :
Amyloid beta (Abeta) and cholinesterase enzymes (AChE, BuChE) are important biological targets for the effective treatment of Alzheimer's disease. In this study, the aim was to synthesize new donepezil-like secondary amide compounds that display a potent inhibition of cholinesterases and Abeta with antioxidant and metal chelation abilities. All test compounds showed activities against both ChEs and beta1-42 inhibition. The most encouraging compound, 20, is an AChE inhibitor with high anti-aggregation activity (55.3%). Based on the results, compound 20 may be a promising structure in further research for new anti-Alzheimer's agents. |
| PubMedSearch : Yerdelen_2015_Bioorg.Med.Chem.Lett_25_5576 |
| PubMedID: 26514744 |
Yerdelen KO, Koca M, Anil B, Sevindik H, Kasap Z, Halici Z, Turkaydin K, Gunesacar G (2015)
Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease
Bioorganic & Medicinal Chemistry Lett
25 :5576
Yerdelen KO, Koca M, Anil B, Sevindik H, Kasap Z, Halici Z, Turkaydin K, Gunesacar G (2015)
Bioorganic & Medicinal Chemistry Lett
25 :5576