| Title : Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation - Yoshinari_1994_J.Antibiot.(Tokyo)_47_1376 |
| Author(s) : Yoshinari K , Aoki M , Ohtsuka T , Nakayama N , Itezono Y , Mutoh M , Watanabe J , Yokose K |
| Ref : J Antibiot (Tokyo) , 47 :1376 , 1994 |
|
Abstract :
Panclicins A-E are novel and potent pancreatic lipase inhibitors produced by Streptomyces sp. NR 0619. Their structures have been elucidated based on NMR and FAB-MS experiments. The relative configurations have also been determined by NMR experiments. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates of panclicins A and B and by modified Mosher's method on a derivative of panclicin A. They are structurally related to beta-lactone esterase inhibitors of microbial origin, lipstatin, valilactone, ebelactones and esterastin. Panclicins also contain a beta-lactone structure with two alkyl chains, one of which has an N-formylalanyloxy or N-formylglycyloxy substituent. |
| PubMedSearch : Yoshinari_1994_J.Antibiot.(Tokyo)_47_1376 |
| PubMedID: 7844032 |
| Inhibitor | Panclicin-D |
Yoshinari K, Aoki M, Ohtsuka T, Nakayama N, Itezono Y, Mutoh M, Watanabe J, Yokose K (1994)
Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation
J Antibiot (Tokyo)
47 :1376
Yoshinari K, Aoki M, Ohtsuka T, Nakayama N, Itezono Y, Mutoh M, Watanabe J, Yokose K (1994)
J Antibiot (Tokyo)
47 :1376