Title : Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3 - Yost_2020_Int.J.Mol.Sci_21_ |
Author(s) : Yost RT , Robinson JW , Baxter CM , Scott AM , Brown LP , Aletta MS , Hakimjavadi R , Lone A , Cumming RC , Dukas R , Mozer B , Simon AF |
Ref : Int J Mol Sci , 21 : , 2020 |
Abstract :
Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and aggression, in simpler organisms such as Drosophila melanogaster. Here, we examined the effects of mutants of the autism-related gene neuroligin 3 (nlg3) on fly social and non-social behaviors. Startled-induced negative geotaxis is affected by a loss of function nlg3 mutation. Social space and aggression are also altered in a sex- and social-experience-specific manner in nlg3 mutant flies. In light of the conserved roles that neuroligins play in social behavior, our results offer insight into the regulation of social behavior in other organisms, including humans. |
PubMedSearch : Yost_2020_Int.J.Mol.Sci_21_ |
PubMedID: 32610435 |
Gene_locus related to this paper: drome-nlg3 |
Mutation | KO\/deltot_drome-nlg3 |
Gene_locus | drome-nlg3 |
Yost RT, Robinson JW, Baxter CM, Scott AM, Brown LP, Aletta MS, Hakimjavadi R, Lone A, Cumming RC, Dukas R, Mozer B, Simon AF (2020)
Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3
Int J Mol Sci
21 :
Yost RT, Robinson JW, Baxter CM, Scott AM, Brown LP, Aletta MS, Hakimjavadi R, Lone A, Cumming RC, Dukas R, Mozer B, Simon AF (2020)
Int J Mol Sci
21 :