Yost_2020_Int.J.Mol.Sci_21_

Reference

Title : Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3 - Yost_2020_Int.J.Mol.Sci_21_
Author(s) : Yost RT , Robinson JW , Baxter CM , Scott AM , Brown LP , Aletta MS , Hakimjavadi R , Lone A , Cumming RC , Dukas R , Mozer B , Simon AF
Ref : Int J Mol Sci , 21 : , 2020
Abstract :

Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and aggression, in simpler organisms such as Drosophila melanogaster. Here, we examined the effects of mutants of the autism-related gene neuroligin 3 (nlg3) on fly social and non-social behaviors. Startled-induced negative geotaxis is affected by a loss of function nlg3 mutation. Social space and aggression are also altered in a sex- and social-experience-specific manner in nlg3 mutant flies. In light of the conserved roles that neuroligins play in social behavior, our results offer insight into the regulation of social behavior in other organisms, including humans.

PubMedSearch : Yost_2020_Int.J.Mol.Sci_21_
PubMedID: 32610435
Gene_locus related to this paper: drome-nlg3

Related information

Mutation KO\/deltot_drome-nlg3
Gene_locus drome-nlg3

Citations formats

Yost RT, Robinson JW, Baxter CM, Scott AM, Brown LP, Aletta MS, Hakimjavadi R, Lone A, Cumming RC, Dukas R, Mozer B, Simon AF (2020)
Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3
Int J Mol Sci 21 :

Yost RT, Robinson JW, Baxter CM, Scott AM, Brown LP, Aletta MS, Hakimjavadi R, Lone A, Cumming RC, Dukas R, Mozer B, Simon AF (2020)
Int J Mol Sci 21 :