| Title : Four new steroids from the endophytic fungus Chaetomium sp. M453 derived of Chinese herbal medicine Huperzia serrata - Yu_2016_Fitoterapia_117_41 |
| Author(s) : Yu FX , Li Z , Chen Y , Yang YH , Li GH , Zhao PJ |
| Ref : Fitoterapia , 117 :41 , 2016 |
|
Abstract :
An endophytic fungus, Chaetomium sp. M453, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation. Three unusual C25 steroids, neocyclocitrinols E-G (1-3), and 3beta-hydroxy-5,9-epoxy-(22E,24R)-ergosta-7,22-dien-6-one (4) together with three known steroids were isolated from solid fermentation products of the fungus, which were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS experiments. The absolute configuration of 1 was determined by X-ray crystallographic analysis and CD analyses. The acetylcholinesterase inhibitory activities of compounds 1-4 were tested in vitro. Compound 4 showed weak acetylcholinesterase inhibitory activity. |
| PubMedSearch : Yu_2016_Fitoterapia_117_41 |
| PubMedID: 28041908 |
Yu FX, Li Z, Chen Y, Yang YH, Li GH, Zhao PJ (2016)
Four new steroids from the endophytic fungus Chaetomium sp. M453 derived of Chinese herbal medicine Huperzia serrata
Fitoterapia
117 :41
Yu FX, Li Z, Chen Y, Yang YH, Li GH, Zhao PJ (2016)
Fitoterapia
117 :41