Yu_2017_Chin.J.Nat.Med_15_732

Reference

Title : Pomegranate leaf attenuates lipid absorption in the small intestine in hyperlipidemic mice by inhibiting lipase activity - Yu_2017_Chin.J.Nat.Med_15_732
Author(s) : Yu X , Wang XP , Lei F , Jiang JF , Li J , Xing DM , Du LJ
Ref : Chin J Nat Med , 15 :732 , 2017
Abstract :

Pomegranate leaf (PGL) has a definite role in regulating lipid metabolism. However, pharmacokinetic results show the main active ingredient, ellagic acid, in PGL has lower oral bioavailability, suggesting that the lipid-lowering effect of PGL may act through inhibiting lipid absorption in the small intestine. Our results demonstrated that pomegranate leaf and its main active ingredients (i.e., ellagic acid, gallic acid, pyrogallic acid and tannic acid) were capable of inhibiting pancreatic lipase activity in vitro. In computational molecular docking, the four ingredients had good affinity for pancreatic lipase. Acute lipid overload experiments showed that a large dosage of PGL significantly reduced serum total cholesterol (TG) and triglycerides (TC) levels in addition to inhibiting intestinal lipase activity, which demonstrated that PGL could inhibit lipase activity and reduce the absorption of lipids. We also found that PGL could reverse the reduced tight-junction protein expression due to intestinal lipid overload, promote Occludin and Claudin4 expression in the small intestine, and enhance the intestinal mucosal barrier. In conclusion, we demonstrated that PGL can inhibit lipid absorption and reduce blood TG and TC by targeting pancreatic lipase, promoting tight-junction protein expression and thereby preventing intestinal mucosa damage from an overload of lipids in the intestine.

PubMedSearch : Yu_2017_Chin.J.Nat.Med_15_732
PubMedID: 29103458

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Citations formats

Yu X, Wang XP, Lei F, Jiang JF, Li J, Xing DM, Du LJ (2017)
Pomegranate leaf attenuates lipid absorption in the small intestine in hyperlipidemic mice by inhibiting lipase activity
Chin J Nat Med 15 :732

Yu X, Wang XP, Lei F, Jiang JF, Li J, Xing DM, Du LJ (2017)
Chin J Nat Med 15 :732