Yu_2020_J.Asian.Nat.Prod.Res__1

Reference

Title : Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities - Yu_2020_J.Asian.Nat.Prod.Res__1
Author(s) : Yu X , Zhao YF , Huang GJ , Chen YF
Ref : J Asian Nat Prod Res , :1 , 2020
Abstract :

Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives were synthesized via iodine-mediated oxidative cyclisation and confirmed by (1)H NMR, (13)C NMR and HRMS. The result of these derivatives' activities inhibiting acetylcholinesterase in vitro showed that 4 g and 4i had moderate inhibitory activities with 69.19% and 65.06%, respectively. The preliminary structure-activity relationships revealed that introduction of halogen atom on the para-position of phenyl of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives could enhance their activities. Molecular docking study suggested that 4 g possessed an optimal docking pose with interactions inside AChE.

PubMedSearch : Yu_2020_J.Asian.Nat.Prod.Res__1
PubMedID: 32815409

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Citations formats

Yu X, Zhao YF, Huang GJ, Chen YF (2020)
Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities
J Asian Nat Prod Res :1

Yu X, Zhao YF, Huang GJ, Chen YF (2020)
J Asian Nat Prod Res :1