Title : [Proteolytic cleavage of neuroligins and functions of their cleavage products] - Yu_2020_Zhejiang.Da.Xue.Xue.Bao.Yi.Xue.Ban_49_514 |
Author(s) : Yu J , Xu J |
Ref : Zhejiang Da Xue Xue Bao Yi Xue Ban , 49 :514 , 2020 |
Abstract :
Neuroligin is a key protein that mediates synaptic development and maturation, and is closely related to neurodevelopmental diseases such as autism. In recent years, researchers have found that neuroligin can be hydrolyzed by various proteases at different stages of development, neuronal activities or pathological states of some neuropsychiatric diseases, thus affecting synaptic activity and participating in the occurrence and development of neurological diseases. The hydrolysates may have different physiological functions from the whole protein, and play different functions in neural activities, such as regulating synaptic plasticity, increasing synaptic strength and number, affecting amyloid-beta polymerization, promoting glioma proliferation and growth, activating related signaling pathways, and so on. In this article, on the basis of elaborating the structure and function of neuroligin as a whole protein, the conditions and products of its hydrolysis are summarized and analyzed, and the functional consequences and physiological significance of its hydrolysis are discussed. |
PubMedSearch : Yu_2020_Zhejiang.Da.Xue.Xue.Bao.Yi.Xue.Ban_49_514 |
PubMedID: 32985166 |
Yu J, Xu J (2020)
[Proteolytic cleavage of neuroligins and functions of their cleavage products]
Zhejiang Da Xue Xue Bao Yi Xue Ban
49 :514
Yu J, Xu J (2020)
Zhejiang Da Xue Xue Bao Yi Xue Ban
49 :514