Yu_2023_J.Lipid.Res__100462

Genetic and biochemical evidence has established DDHD2 as the principal triacylglycerol (TAG) hydrolase in neuronal lipolysis of cytosolic lipid droplets (LD). In this issue of Journal of Lipid Research, Hofer et al. (Ref?) report that DDHD2 cooperates with ATGL, the principal TAG hydrolase in adipose lipolysis, contributing to cytosolic hydrolysis of both TAG and diacylglycerols (DAG) in murine neuroblastoma cells and primary cortical neurons via different configurations of the lipases. This finding highlights the complexity of cytosolic acylglycerol hydrolysis and raises many new questions in the field of lipid metabolism.