| Title : Role of anticholinesterase mechanism in suppression of antibody formation during acute poisoning with organophosphorus compounds - Zabrodskii_2001_Bull.Exp.Biol.Med_131_467 |
| Author(s) : Zabrodskii PF , Kirichuk VF , Germanchuk VG |
| Ref : Bulletin of Experimental Biology & Medicine , 131 :467 , 2001 |
|
Abstract :
Experiments on Wistar rats showed that acute poisoning with organophosphorus compound dimethyl dichlorovinyl phosphate (0.5 LD(50)) was accompanied by two opposite effects: inhibition of acetylcholinesterase in T lymphocytes leading to suppression of thymus-dependent antibody formation (predominant effect) and acetylcholine-induced stimulation of antibody production. Acetylcholine activated acetylcholinesterase in intact T cells. |
| PubMedSearch : Zabrodskii_2001_Bull.Exp.Biol.Med_131_467 |
| PubMedID: 11550055 |
Zabrodskii PF, Kirichuk VF, Germanchuk VG (2001)
Role of anticholinesterase mechanism in suppression of antibody formation during acute poisoning with organophosphorus compounds
Bulletin of Experimental Biology & Medicine
131 :467
Zabrodskii PF, Kirichuk VF, Germanchuk VG (2001)
Bulletin of Experimental Biology & Medicine
131 :467