Title : Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil - Zachow_2016_Nat.Prod.Res__1 |
Author(s) : Zachow LL , Avila JM , Saldanha GA , Mostardeiro MA , da Silva UF , Morel AF , Dalcol, II |
Ref : Nat Prod Res , :1 , 2016 |
Abstract :
Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid leojaponin, the phytosterols beta-sitosterol and beta-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors. Extracts obtained by maceration were active against POP (53-58%), but showed weak activity against AChE. The isolated leojaponin and leonurine were evaluated as POP inhibitors. |
PubMedSearch : Zachow_2016_Nat.Prod.Res__1 |
PubMedID: 27834099 |
Zachow LL, Avila JM, Saldanha GA, Mostardeiro MA, da Silva UF, Morel AF, Dalcol, II (2016)
Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil
Nat Prod Res
:1
Zachow LL, Avila JM, Saldanha GA, Mostardeiro MA, da Silva UF, Morel AF, Dalcol, II (2016)
Nat Prod Res
:1