| Title : Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol - Zambon_1998_Arterioscler.Thromb.Vasc.Biol_18_1723 |
| Author(s) : Zambon A , Deeb SS , Hokanson JE , Brown BG , Brunzell JD |
| Ref : Arterioscler Thromb Vasc Biol , 18 :1723 , 1998 |
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Abstract :
Increased hepatic lipase (HL) activity is associated with small, dense, low density lipoprotein (LDL) and low high density lipoprotein2 (HDL2) cholesterol (-C) levels. A polymorphism in the promoter region of the HL gene (LIPC) is associated with HDL-C levels. To test whether this association is mediated by differences in HL activity between different LIPC promoter genotypes, the LIPC promoter polymorphism at position -250 (G-->A), HL activity, LDL buoyancy, and HDL-C levels were studied in white normolipidemic men and men with coronary artery disease (CAD). The less common A allele (frequency=0.21 and 0.25 in normal and CAD subjects, respectively) was associated with lower HL activity (P<0.005 by ANOVA) and buoyant LDL particles (P |
| PubMedSearch : Zambon_1998_Arterioscler.Thromb.Vasc.Biol_18_1723 |
| PubMedID: 9812910 |
| Mutation | Prom-250A_human-LIPC |
| Disease | Hepatic triglyceride lipase Deficiency |
Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD (1998)
Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol
Arterioscler Thromb Vasc Biol
18 :1723
Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD (1998)
Arterioscler Thromb Vasc Biol
18 :1723