| Title : Reduction in muscarinic receptors by antisense oligodeoxynucleotide - Zang_1994_Biochem.Pharmacol_48_225 |
| Author(s) : Zang Z , Florijn W , Creese I |
| Ref : Biochemical Pharmacology , 48 :225 , 1994 |
|
Abstract :
Treatment of rat superior cervical ganglion cells in culture for 4 days with an antisense oligodeoxynucleotide corresponding to a partial sequence of the mRNA coding the m1 muscarinic receptor decreased m1 receptor mRNA by 64% without affecting m2 receptor mRNA. [3H]Pirenzepine binding to M1 receptors was decreased by 43%. Intraventricular infusion of this antisense oligodeoxynucleotide reduced muscarinic receptor density in M1 but not M2 receptor-rich brain regions. |
| PubMedSearch : Zang_1994_Biochem.Pharmacol_48_225 |
| PubMedID: 8053918 |
Zang Z, Florijn W, Creese I (1994)
Reduction in muscarinic receptors by antisense oligodeoxynucleotide
Biochemical Pharmacology
48 :225
Zang Z, Florijn W, Creese I (1994)
Biochemical Pharmacology
48 :225