| Title : A novel traceless resin-bound guanidinylating reagent for secondary amines to prepare N,N-disubstituted guanidines - Zapf_2001_Org.Lett_3_1133 |
| Author(s) : Zapf CW , Creighton CJ , Tomioka M , Goodman M |
| Ref : Org Lett , 3 :1133 , 2001 |
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Abstract :
[reaction: see text]. We report the development of a solid support-linked guanidinylating reagent. This reagent consists of a urethane-protected triflyl guanidine attached to the resin via a carbamate linker. It allows for rapid synthesis of guanidines from a variety of amines. It provides access to N-alkyl/aryl- or N,N-dialkylguanidines under mild conditions. Cleavage with 50% TFA produces target molecules in high yields and purity. The ability to guanidinylate secondary amines is a significant feature of this guanidinylating reagent. |
| PubMedSearch : Zapf_2001_Org.Lett_3_1133 |
| PubMedID: 11348177 |
Zapf CW, Creighton CJ, Tomioka M, Goodman M (2001)
A novel traceless resin-bound guanidinylating reagent for secondary amines to prepare N,N-disubstituted guanidines
Org Lett
3 :1133
Zapf CW, Creighton CJ, Tomioka M, Goodman M (2001)
Org Lett
3 :1133