| Title : Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species - Zatta_1994_Neuroreport_5_1777 |
| Author(s) : Zatta P , Zambenedetti P , Bruna V , Filippi B |
| Ref : Neuroreport , 5 :1777 , 1994 |
|
Abstract :
The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The interaction between Al3+ and gamma-peripheral sites of the enzyme produces AChE structural modifications as evidenced by circular dichroism measurements. This may provide a molecular explanation of the raised enzymatic activity. |
| PubMedSearch : Zatta_1994_Neuroreport_5_1777 |
| PubMedID: 7827330 |
Zatta P, Zambenedetti P, Bruna V, Filippi B (1994)
Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species
Neuroreport
5 :1777
Zatta P, Zambenedetti P, Bruna V, Filippi B (1994)
Neuroreport
5 :1777