Title : Paraoxonase 1 and cytochrome P450 polymorphisms in susceptibility to acute organophosphorus poisoning in Egyptians - Zayed_2015_Neurotoxicol_51_20 |
Author(s) : Zayed AA , Ahmed AI , Khattab AM , Mekdad AA , AbdelAal AG |
Ref : Neurotoxicology , 51 :20 , 2015 |
Abstract :
BACKGROUND: Organophosphates are the basis of many insecticides, herbicides, and nerve agents. They were listed as highly acutely toxic agents. Findings in knockout mice suggest that paraoxonase 1 may modulate the toxicity resulting from exposure to organophosphorus compounds. In human, there is no enough data about genetic modulation of acute organophosphorus intoxication. CYP2D6 is involved in the metabolism of about 30% of xenobiotics. Prompt accurate management of OP acute intoxication can promote patient's survival. DESIGN AND |
PubMedSearch : Zayed_2015_Neurotoxicol_51_20 |
PubMedID: 26340881 |
Zayed AA, Ahmed AI, Khattab AM, Mekdad AA, AbdelAal AG (2015)
Paraoxonase 1 and cytochrome P450 polymorphisms in susceptibility to acute organophosphorus poisoning in Egyptians
Neurotoxicology
51 :20
Zayed AA, Ahmed AI, Khattab AM, Mekdad AA, AbdelAal AG (2015)
Neurotoxicology
51 :20