| Title : Screening for acetylcholinesterase inhibitory activity in cyanobacteria of the genus Nostoc - Zelik_2009_J.Enzyme.Inhib.Med.Chem_24_531 |
| Author(s) : Zelik P , Lukesova A , Voloshko LN , Stys D , Kopecky J |
| Ref : J Enzyme Inhib Med Chem , 24 :531 , 2009 |
| Abstract : Fifty-four cyanobacterial strains of the genus Nostoc from different habitats were screened for acetylcholinesterase inhibitory activity. Water-methanolic extracts from freeze-dried biomasses were tested for inhibitory activity using Ellman's spectrophotometric method. Acetylcholinesterase inhibitory activity higher than 90% was found in the crude extracts of Nostoc sp. str. Lukesova 27/97 and Nostoc ellipsosporum Rabenh. str. Lukesova 51/91. Extracts from Nostoc ellipsosporum str. Lukesova 52/91 and Nostoc linckia f. muscorum (Ag.) Elenk. str. Gromov, 1988, CALU-980 inhibited AChE activity by 84.9% and 65.3% respectively. Moderate AChE inhibitory activity (29.1-37.5%) was found in extracts of Nostoc linckia Roth. str. Gromov, 1962/10, CALU-129, Nostoc muscorum Ag. str. Lukesova 127/97, Nostoc sp. str. Lhotsky, CALU-327 and Nostoc sp. str. Gromov, CALU-998. Extracts from another seven strains showed weak anti-AChE activities. The active component responsible for acetylcholinesterase inhibition was identified in a crude extract of Nostoc sp. str. Lukesova 27/97 using HPLC and found to occur in one single peak. |
| ESTHER : Zelik_2009_J.Enzyme.Inhib.Med.Chem_24_531 |
| PubMedSearch : Zelik_2009_J.Enzyme.Inhib.Med.Chem_24_531 |
| PubMedID: 18951237 |
Zelik P, Lukesova A, Voloshko LN, Stys D, Kopecky J (2009)
Screening for acetylcholinesterase inhibitory activity in cyanobacteria of the genus Nostoc
J Enzyme Inhib Med Chem
24 :531
Zelik P, Lukesova A, Voloshko LN, Stys D, Kopecky J (2009)
J Enzyme Inhib Med Chem
24 :531