| Title : Chemical composition, antibacterial, antioxidant, and anticholinesterase activities, in vitro and in silico, of the essential oil of Algerian endemic species Daucus biseriatus Murb - Zellagui_2024_Int.J.Environ.Health.Res__1 |
| Author(s) : Zellagui DR , Chemsa AEK , Hadjab W , Halis Y , Ozturk M , Boutellaa S , Zellagui A , Gherraf N |
| Ref : Int J Environ Health Res , :1 , 2024 |
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Abstract :
This study investigated the chemical composition and biological activities of essential oils extracted from Daucus biseriatus collected from the Algerian Sahara. Gas chromatography-mass spectrometry identified 57 compounds, constituting 97.09% of the oils, with myristicin (23.88%), methylogenol (22.60%), elemicin (7.86%), and delta-cadiene (6.91%) as the main constituents. The oils exhibited significant antimicrobial activity, notably against Staphylococcus aureus, E. coli, and M. luteus, with inhibition zones up to 27 mm. Antioxidant activity was tested using ABTS and linoleic acid methods, yielding IC50 values of >800 microg/mL and 29.62 +/- 3.28 microg/mL, respectively. The oils also showed moderate inhibition of Alzheimer's-related enzymes, acetylcholinesterase and butyrylcholinesterase, with IC50 values >800 microg/mL. Docking studies revealed myristicin as the most potent inhibitor of the LPS transporter (LptE). This pioneering research is the first to report on the essential oils of this plant. . |
| PubMedSearch : Zellagui_2024_Int.J.Environ.Health.Res__1 |
| PubMedID: 39710851 |
Zellagui DR, Chemsa AEK, Hadjab W, Halis Y, Ozturk M, Boutellaa S, Zellagui A, Gherraf N (2024)
Chemical composition, antibacterial, antioxidant, and anticholinesterase activities, in vitro and in silico, of the essential oil of Algerian endemic species Daucus biseriatus Murb
Int J Environ Health Res
:1
Zellagui DR, Chemsa AEK, Hadjab W, Halis Y, Ozturk M, Boutellaa S, Zellagui A, Gherraf N (2024)
Int J Environ Health Res
:1