Zellagui_2025_Chem.Biodivers__e202402684

Reference

Title : Unraveling Chemical Profile, Antioxidant, Antialzheimer and Antimicrobial Potentials of Three Propolis from Northeastern Regions of Algeria: In Vitro and in Silico Evaluation - Zellagui_2025_Chem.Biodivers__e202402684
Author(s) : Zellagui DR , Mokrani EH , Allam A , Ozturk M , Bensouici C , Zellagui A
Ref : Chem Biodivers , :e202402684 , 2025
Abstract :

This study investigates the pharmaceutical potential both in vitro and in silico of ethanolic propolis extract from three Algerian regions namely TAH (Tahir-Jijel), ATH (Oued Athmania-Mila) and OZ (Oued Zhor-skikda). Twenty-three compounds were identified via HPLCDAD, with key constituents including caffeic acid, cynarin, chrysin, naringin, and hesperetin. Moreover, Antioxidant and anti-Alzheimer activities were assessed by multiple assays. Antimicrobial activity was tested against four pathogens and one yeast. The TAH extract showed the highest antioxidant activity, and ATH (Oued Athmania-Mila) exhibited the strongest anticholinesterase activity. Extracts demonstrated potent inhibition against Staphylococcus aureus and Micrococcus luteus ATCC 4698. Docking studies revealed that cynarin was the most potent acetylcholinesterase (AChE) inhibitor, and quercetin was the most potent butyrylcholinesterase (BChE) inhibitor; These compounds were found to bind to both the catalytic site and the peripheral site, showing greater inhibitory potency than galantamine.

PubMedSearch : Zellagui_2025_Chem.Biodivers__e202402684
PubMedID: 39815680

Related information

Citations formats

Zellagui DR, Mokrani EH, Allam A, Ozturk M, Bensouici C, Zellagui A (2025)
Unraveling Chemical Profile, Antioxidant, Antialzheimer and Antimicrobial Potentials of Three Propolis from Northeastern Regions of Algeria: In Vitro and in Silico Evaluation
Chem Biodivers :e202402684

Zellagui DR, Mokrani EH, Allam A, Ozturk M, Bensouici C, Zellagui A (2025)
Chem Biodivers :e202402684