| Title : Synthesis and acetylcholinesterase inhibitory activity of (+\/-)-14- fluorohuperzine A - Zeng_1998_Bioorg.Med.Chem.Lett_8_1661 |
| Author(s) : Zeng F , Jiang H , Tang X , Chen K , Ji R |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :1661 , 1998 |
|
Abstract :
The synthesis of (+/-)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (-)-huperzine A. |
| PubMedSearch : Zeng_1998_Bioorg.Med.Chem.Lett_8_1661 |
| PubMedID: 9873409 |
| Inhibitor | HuperzineA |
Zeng F, Jiang H, Tang X, Chen K, Ji R (1998)
Synthesis and acetylcholinesterase inhibitory activity of (+\/-)-14- fluorohuperzine A
Bioorganic & Medicinal Chemistry Lett
8 :1661
Zeng F, Jiang H, Tang X, Chen K, Ji R (1998)
Bioorganic & Medicinal Chemistry Lett
8 :1661