| Title : Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials - Zengin_2018_Bioorg.Chem_81_119 |
| Author(s) : Zengin M , Genc H , Taslimi P , Kestane A , Guclu E , Ogutlu A , Karabay O , Gulcin I |
| Ref : Bioorg Chem , 81 :119 , 2018 |
|
Abstract :
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P. aeruginosa, E. coli and S. aureus strains were investigated with agar well diffusion method. The results were compared with commercially available drug active compounds. As well as 3a, 3b and 3c have the most significant antibacterial effect among all the tested compounds; approximately all of them have more antibacterial activity than the reference drugs. These novel thymol bearing oxypropanolamine derivatives were effective inhibitors of the alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase enzymes (AChE) with Ki values in the range of 463.85-851.05microM for alpha-glycosidase, 1.11-17.34microM for hCA I, 2.97-17.83microM for hCA II, and 13.58-31.45microM for AChE, respectively. |
| PubMedSearch : Zengin_2018_Bioorg.Chem_81_119 |
| PubMedID: 30118983 |
Zengin M, Genc H, Taslimi P, Kestane A, Guclu E, Ogutlu A, Karabay O, Gulcin I (2018)
Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors - Their antidiabetic, anticholinergic and antibacterial potentials
Bioorg Chem
81 :119
Zengin M, Genc H, Taslimi P, Kestane A, Guclu E, Ogutlu A, Karabay O, Gulcin I (2018)
Bioorg Chem
81 :119