| Title : Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities - Zhan_2010_Bioorg.Med.Chem.Lett_20_1532 |
| Author(s) : Zhan ZJ , Bian HL , Wang JW , Shan WG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1532 , 2010 |
|
Abstract :
A series of physostigmine analogues were prepared and evaluated for cholinesterase inhibition activities, including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Most of them showed potent inhibition activities against AChE, in which compound 17 especially exhibited significantly higher selectivity over BChE than phenserine, a compound currently on clinical trial. Discussion about the relationships between structure and activity of these derivatives was also presented. |
| PubMedSearch : Zhan_2010_Bioorg.Med.Chem.Lett_20_1532 |
| PubMedID: 20144867 |
Zhan ZJ, Bian HL, Wang JW, Shan WG (2010)
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities
Bioorganic & Medicinal Chemistry Lett
20 :1532
Zhan ZJ, Bian HL, Wang JW, Shan WG (2010)
Bioorganic & Medicinal Chemistry Lett
20 :1532