Title : Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities - Zhan_2010_Bioorg.Med.Chem.Lett_20_6185 |
Author(s) : Zhan ZJ , Yu Q , Wang ZL , Shan WG |
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6185 , 2010 |
Abstract :
Through bioassay-guided fractionation and chromatography technique, eight indole alkaloids were furnished from the stems of Ervatamia hainanensis. All isolates were evaluated for acetylcholinesterase (AChE) inhibition activities, in which compounds 1 and 3 exhibited the same level of activities as galantamine, a marketed cholinesterase inhibitor for the treatment of Alzheimer's disease. Discussion about the relationships between structure and activity of these alkaloids was also presented. |
PubMedSearch : Zhan_2010_Bioorg.Med.Chem.Lett_20_6185 |
PubMedID: 20850311 |
Zhan ZJ, Yu Q, Wang ZL, Shan WG (2010)
Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities
Bioorganic & Medicinal Chemistry Lett
20 :6185
Zhan ZJ, Yu Q, Wang ZL, Shan WG (2010)
Bioorganic & Medicinal Chemistry Lett
20 :6185