| Title : Similar potency of the enantiomers of huperzine A in inhibition of [(3)H]dizocilpine (MK-801) binding in rat cerebral cortex - Zhang_2000_Neurosci.Lett_295_116 |
| Author(s) : Zhang YH , Chen XQ , Yang HH , Jin GY , Bai DL , Hu GY |
| Ref : Neuroscience Letters , 295 :116 , 2000 |
|
Abstract :
The inhibition of huperzine A, a potential therapeutic agent to treat Alzheimer's disease, on rat cortical acetylcholinesterase was found to be highly stereospecific. In the present study the effect of the enantiomers of huperzine A on [(3)H]dizocilpine (MK-801) binding to synaptic membrane of rat cerebral cortex was compared. The natural (-)-huperzine A and the synthetic (+)-huperzine A inhibited the specific binding of [(3)H]MK-801 with a similar potency. The IC(50) values were 65+/-7 and 82+/-12 microM (n=5 for each enantiomer, P=0.248), respectively. The result indicates that huperzine A inhibits N-methyl-D-aspartate (NMDA) receptor in rat cerebral cortex without stereoselectivity. |
| PubMedSearch : Zhang_2000_Neurosci.Lett_295_116 |
| PubMedID: 11090988 |
Zhang YH, Chen XQ, Yang HH, Jin GY, Bai DL, Hu GY (2000)
Similar potency of the enantiomers of huperzine A in inhibition of [(3)H]dizocilpine (MK-801) binding in rat cerebral cortex
Neuroscience Letters
295 :116
Zhang YH, Chen XQ, Yang HH, Jin GY, Bai DL, Hu GY (2000)
Neuroscience Letters
295 :116