| Title : Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons - Zhang_2001_Brain.Res_919_166 |
| Author(s) : Zhang XF , McKenna DG , Briggs CA |
| Ref : Brain Research , 919 :166 , 2001 |
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Abstract :
In patch-clamp recordings from small-medium diameter dorsal root ganglion neurons in culture, (+/-)-epibatidine (1 microM) was able to inhibit the capsaicin response (IC(50)=0.32 microM) in neurons where there was no detectable direct nicotinic response. Thus, (+/-)-epibatidine may inhibit the vanilloid receptor in a manner that is not dependent upon nicotinic current activation, representing another mechanism by which such ligands could modulate vanilloid receptor signaling. |
| PubMedSearch : Zhang_2001_Brain.Res_919_166 |
| PubMedID: 11689175 |
Zhang XF, McKenna DG, Briggs CA (2001)
Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons
Brain Research
919 :166
Zhang XF, McKenna DG, Briggs CA (2001)
Brain Research
919 :166