Title : Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men - Zhang_2005_Am.J.Clin.Nutr_81_1429 |
Author(s) : Zhang C , Lopez-Ridaura R , Rimm EB , Rifai N , Hunter DJ , Hu FB |
Ref : Am J Clin Nutr , 81 :1429 , 2005 |
Abstract :
BACKGROUND: Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. A common polymorphism (-514C-->T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations. OBJECTIVE: We examined the association between this polymorphism and plasma HDL-cholesterol concentrations and evaluated whether this association was modified by adiposity and dietary fat intake. DESIGN: We followed men aged 40-75 y who participated in the Health Professionals Follow-Up Study in 1986. Among 18 159 men who returned blood samples by 1994, 780 had confirmed type 2 diabetes at blood drawing or during follow-up to 1998 and were free of cardiovascular disease at blood drawing. |
PubMedSearch : Zhang_2005_Am.J.Clin.Nutr_81_1429 |
PubMedID: 15941898 |
Mutation | Prom-514T_human-LIPC |
Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB (2005)
Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men
Am J Clin Nutr
81 :1429
Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB (2005)
Am J Clin Nutr
81 :1429