Zhang_2005_Am.J.Clin.Nutr_81_1429

Reference

Title : Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men - Zhang_2005_Am.J.Clin.Nutr_81_1429
Author(s) : Zhang C , Lopez-Ridaura R , Rimm EB , Rifai N , Hunter DJ , Hu FB
Ref : Am J Clin Nutr , 81 :1429 , 2005
Abstract :

BACKGROUND: Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. A common polymorphism (-514C-->T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations. OBJECTIVE: We examined the association between this polymorphism and plasma HDL-cholesterol concentrations and evaluated whether this association was modified by adiposity and dietary fat intake. DESIGN: We followed men aged 40-75 y who participated in the Health Professionals Follow-Up Study in 1986. Among 18 159 men who returned blood samples by 1994, 780 had confirmed type 2 diabetes at blood drawing or during follow-up to 1998 and were free of cardiovascular disease at blood drawing.
RESULTS: After adjustment for age, smoking, alcohol consumption, fasting status, glycated hemoglobin concentration, physical activity, and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T or T/T genotype than in those with the C/C genotype (adjusted x: 40.9 and 38.8 mg/dL, respectively; P = 0.01). We observed significant LIPC -514 polymorphism x body mass index and LIPC -514 polymorphism x saturated fat intake interactions for HDL-cholesterol concentrations (P = 0.003 for both). The T allele was associated with higher HDL-cholesterol concentrations only in men who were not overweight or who had higher saturated fat intake. CONCLUSION: Our study suggests that the effects of -514C-->T of the LIPC gene on HDL concentrations were modified by saturated fat intake and obesity.

PubMedSearch : Zhang_2005_Am.J.Clin.Nutr_81_1429
PubMedID: 15941898

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Citations formats

Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB (2005)
Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men
Am J Clin Nutr 81 :1429

Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB (2005)
Am J Clin Nutr 81 :1429