| Title : Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products - Zhang_2011_Chem.Biol.Drug.Des_78_94 |
| Author(s) : Zhang H , Jin H , Ji LZ , Tao K , Liu W , Zhao HY , Hou TP |
| Ref : Chemical Biology Drug Des , 78 :94 , 2011 |
|
Abstract :
Three natural products, 1,5-diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity. All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities. Compound III with a furyl ring showed strong activities against plant pathogenic fungi. The IC(50) of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III(2) ) was 1.20 mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug. |
| PubMedSearch : Zhang_2011_Chem.Biol.Drug.Des_78_94 |
| PubMedID: 21457470 |
Zhang H, Jin H, Ji LZ, Tao K, Liu W, Zhao HY, Hou TP (2011)
Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products
Chemical Biology Drug Des
78 :94
Zhang H, Jin H, Ji LZ, Tao K, Liu W, Zhao HY, Hou TP (2011)
Chemical Biology Drug Des
78 :94