| Title : Synthesis and evaluation of coumarin\/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity - Zhang_2018_J.Asian.Nat.Prod.Res__1 |
| Author(s) : Zhang J , Li JC , Song JL , Cheng ZQ , Sun JZ , Jiang CS |
| Ref : J Asian Nat Prod Res , :1 , 2018 |
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Abstract :
A series of new coumarin/1,2,4-oxadiazole hybrids were synthesized and evaluated for cholinesterase inhibitory and neuroprotective activities. Among them, enantiomers 5u and 5v showed potent hBChE inhibitory activity with IC50 values of 8.17 and 9.56 muM, respectively, and also exhibited good selectivity for hBChE over hAChE by 9.49- and 7.58-fold, respectively. In addition, both compounds could protect SH-SY5Y cells against Abeta25-35-induced neurotoxicity. The preliminary bioassay results provided a new chemotype for multifunctional anti-Alzheimer's disease agents and continuing investigation into compounds 5u and 5v is warranted. |
| PubMedSearch : Zhang_2018_J.Asian.Nat.Prod.Res__1 |
| PubMedID: 29991292 |
Zhang J, Li JC, Song JL, Cheng ZQ, Sun JZ, Jiang CS (2018)
Synthesis and evaluation of coumarin\/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity
J Asian Nat Prod Res
:1
Zhang J, Li JC, Song JL, Cheng ZQ, Sun JZ, Jiang CS (2018)
J Asian Nat Prod Res
:1