Zhang_2024_Trends.Endocrinol.Metab__

Reference

Title : A unified model for regulating lipoprotein lipase activity - Zhang_2024_Trends.Endocrinol.Metab__
Author(s) : Zhang R , Zhang K
Ref : Trends Endocrinol Metab , : , 2024
Abstract :

The regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions as a molecular switch, through complex formation, activating ANGPTL3 while deactivating ANGPTL4 in their LPL inhibition. The ANGPTL3-4-8 model integrates the roles of the aforementioned proteins in TG partitioning between white adipose tissue (WAT) and oxidative tissues (heart and skeletal muscles) during the feed/fast cycle. This model offers a unified perspective on LPL regulation, providing insights into TG metabolism, metabolic diseases, and therapeutics.

PubMedSearch : Zhang_2024_Trends.Endocrinol.Metab__
PubMedID: 38521668

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Citations formats

Zhang R, Zhang K (2024)
A unified model for regulating lipoprotein lipase activity
Trends Endocrinol Metab :

Zhang R, Zhang K (2024)
Trends Endocrinol Metab :