Zhang_2024_Ultrason.Sonochem_105_106865

Reference

Title : Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of alpha-glucosidase and porcine pancreatic lipase in vitro - Zhang_2024_Ultrason.Sonochem_105_106865
Author(s) : Zhang X , Huang Y , Huang S , Xie W , Huang W , Chen Y , Li Q , Zeng F , Liu X
Ref : Ultrason Sonochem , 105 :106865 , 2024
Abstract :

To further enhance the application of nobiletin (an important active ingredient in Citrus fruits), we used ultrasonic homogenization-assisted antisolvent precipitation to create ultrafine particles of nobiletin (UPN). DMSO was used as the solvent, and deionized water was used as the antisolvent. When ultrasonication (670 W) and homogenization (16000 r/min) were synergistic, the solution concentration was 57 mg/mL, and the minimum particle size of UPN was 521.02 nm. The UPN samples outperformed the RN samples in terms of the inhibition of porcine pancreatic lipase, which was inhibited (by 500 mg/mL) by 68.41 % in the raw sample, 90.34 % in the ultrafine sample, and 83.59 % in the positive control, according to the data. Fourier transform infrared spectroscopy analysis revealed no chemical changes in the samples before or after preparation. However, the crystallinity of the processed ultrafine nobiletin particles decreased. Thus, this work offers significant relevance for applications in the realm of food chemistry and indirectly illustrates the expanded application potential of nobiletin.

PubMedSearch : Zhang_2024_Ultrason.Sonochem_105_106865
PubMedID: 38564909

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Citations formats

Zhang X, Huang Y, Huang S, Xie W, Huang W, Chen Y, Li Q, Zeng F, Liu X (2024)
Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of alpha-glucosidase and porcine pancreatic lipase in vitro
Ultrason Sonochem 105 :106865

Zhang X, Huang Y, Huang S, Xie W, Huang W, Chen Y, Li Q, Zeng F, Liu X (2024)
Ultrason Sonochem 105 :106865