| Title : Photo\/Copper-Catalyzed Oxidative Direct Diphosphorothiolation of Indolin-2-ones with P(O)SH Compounds - Zhang_2026_J.Org.Chem_91_11141 |
| Author(s) : Zhang P , Guo X , Yang M , Cai Y , Wang L , Gao Y |
| Ref : J Org Chem , 91 :11141 , 2026 |
|
Abstract :
A visible-light-promoted cross-dehydrogenative coupling (CDC) of indolin-2-ones with S-hydrogen phosphorothioates via 4H elimination has been developed, providing 3,3-diphosphorothiolated oxindoles in good yields with broad functional group tolerance. The protocol was also extended to monophosphorothiolation and late-stage diversification of drug-derived substrates. Notably, the products displayed potent and selective butyrylcholinesterase (BuChE) inhibitory activity, suggesting potential as leads for Alzheimer's disease. |
| PubMedSearch : Zhang_2026_J.Org.Chem_91_11141 |
| PubMedID: 42599498 |
Zhang P, Guo X, Yang M, Cai Y, Wang L, Gao Y (2026)
Photo\/Copper-Catalyzed Oxidative Direct Diphosphorothiolation of Indolin-2-ones with P(O)SH Compounds
J Org Chem
91 :11141
Zhang P, Guo X, Yang M, Cai Y, Wang L, Gao Y (2026)
J Org Chem
91 :11141