| Title : Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity - Zhao_2020_Phytochemistry_181_112566 |
| Author(s) : Zhao Q , Zhu WT , Ding X , Huo ZQ , Donkor PO , Adelakun TA , Hao XJ , Zhang Y |
| Ref : Phytochemistry , 181 :112566 , 2020 |
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Abstract :
Fourteen undescribed monoterpenoid indole alkaloids, voacafrines A-N, along with 7 known monoterpenoid indole alkaloids were isolated from the seeds of Voacanga africana Stapf. Among them, voacafrines A-G were aspidosperma-aspidosperma type bisindole alkaloids, while voacafrines H-N were aspidosperma-type monomers. Their structures and absolute configurations were elucidated by a combination of NMR, MS, and ECD analyses. Voacafrines A-C were characterized by an acetonyl moiety at C-5', while voacafrine H possessed a methoxymethyl moiety at C-14 within aspidosperma-type alkaloids. The acetylcholinesterase (AChE) inhibitory activity and cytotoxicity of voacafrines A-N were evaluated. Voacafrines A-C and E-G were bisindole alkaloids that exhibited AChE inhibitory activity with IC(50) values of 4.97-33.28 M, while voacafrines I and J were monomers that showed cytotoxicity against several human cancer cell lines with IC(50) values of 4.45-7.49 M. |
| PubMedSearch : Zhao_2020_Phytochemistry_181_112566 |
| PubMedID: 33197743 |
Zhao Q, Zhu WT, Ding X, Huo ZQ, Donkor PO, Adelakun TA, Hao XJ, Zhang Y (2020)
Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity
Phytochemistry
181 :112566
Zhao Q, Zhu WT, Ding X, Huo ZQ, Donkor PO, Adelakun TA, Hao XJ, Zhang Y (2020)
Phytochemistry
181 :112566