| Title : Bufotenine and its derivatives: synthesis, analgesic effects identification and computational target prediction - Zhao_2021_Chin.J.Nat.Med_19_454 |
| Author(s) : Zhao C , Chen M , Sun SL , Wang JJ , Zhong Y , Chen HH , Li HM , Xu H , Li NG , Ma HY , Wang XL |
| Ref : Chin J Nat Med , 19 :454 , 2021 |
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Abstract :
Natural product bufotenine (5) which could be isolated from Venenum Bufonis, has been widely used as a tool in central nervous system (CNS) studies. We present here its quaternary ammonium salt (6) which was synthesized with high yields using 5-benzyloxyindole as raw materials, and we firstly discover its analgesic effects in vivo. The analgesic evaluation showed that compounds 5 and 6 had stronger effects on the behavior of formalin induced pain in mice. Moreover, the combination of compound 6 and morphine has a synergistic effect. We intended to explain the molecular mechanism of this effect. Therefore, 36 analgesic-related targets (including 15 G protein-coupled receptors, 6 enzymes, 13 ion channels, and 2 others) were systemically evaluated using reverse docking. The results indicate that bufotenine and its derivatives are closely related to acetyl cholinesterase (AChE) or alpha(4)beta(2) nicotinic acetylcholine receptor (nAChR). This study provides practitioners a new insight of analgesic effects. |
| PubMedSearch : Zhao_2021_Chin.J.Nat.Med_19_454 |
| PubMedID: 34092296 |
Zhao C, Chen M, Sun SL, Wang JJ, Zhong Y, Chen HH, Li HM, Xu H, Li NG, Ma HY, Wang XL (2021)
Bufotenine and its derivatives: synthesis, analgesic effects identification and computational target prediction
Chin J Nat Med
19 :454
Zhao C, Chen M, Sun SL, Wang JJ, Zhong Y, Chen HH, Li HM, Xu H, Li NG, Ma HY, Wang XL (2021)
Chin J Nat Med
19 :454