| Title : Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase - Zheng_2003_Bioorg.Med.Chem.Lett_13_1787 |
| Author(s) : Zheng QH , Liu X , Fei X , Wang JQ , Mock BH , Glick-Wilson BE , Sullivan ML , Hutchins GD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :1787 , 2003 |
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Abstract :
[11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[11C]methylation of precursors using [11C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure in 50-65% radiochemical yields. |
| PubMedSearch : Zheng_2003_Bioorg.Med.Chem.Lett_13_1787 |
| PubMedID: 12729665 |
Zheng QH, Liu X, Fei X, Wang JQ, Mock BH, Glick-Wilson BE, Sullivan ML, Hutchins GD (2003)
Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett
13 :1787
Zheng QH, Liu X, Fei X, Wang JQ, Mock BH, Glick-Wilson BE, Sullivan ML, Hutchins GD (2003)
Bioorganic & Medicinal Chemistry Lett
13 :1787