Title : New biologically active triterpenoid saponins from Scabiosa tschiliensis - Zheng_2004_J.Nat.Prod_67_604 |
Author(s) : Zheng Q , Koike K , Han LK , Okuda H , Nikaido T |
Ref : Journal of Natural Products , 67 :604 , 2004 |
Abstract :
Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7, 9), hookerosides A, B (12, 13), and prosapogenin 1b all exhibited strong inhibition of pancreatic lipase in vitro. |
PubMedSearch : Zheng_2004_J.Nat.Prod_67_604 |
PubMedID: 15104490 |
Zheng Q, Koike K, Han LK, Okuda H, Nikaido T (2004)
New biologically active triterpenoid saponins from Scabiosa tschiliensis
Journal of Natural Products
67 :604
Zheng Q, Koike K, Han LK, Okuda H, Nikaido T (2004)
Journal of Natural Products
67 :604