| Title : Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues - Zhou_2008_Bioorg.Med.Chem_16_8011 |
| Author(s) : Zhou X , Wang XB , Wang T , Kong LY |
| Ref : Bioorganic & Medicinal Chemistry , 16 :8011 , 2008 |
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Abstract :
Three series (series A-C) of coumarin analogues with phenylpiperazine functions as substitution were designed and synthesized for studying their potential for treating Alzheimer's (AD) disease. Their anticholinesterase activities were assayed according to Ellmann's method against freshly prepared acetylcholinesterase (AChE) from Electrophorus electricus using donepezil as the reference compound. Pharmacological study and preliminary structure-activity relationships showed that coumarins with substitution on positions 3 and/or 4 have parallel anti-AchE activities compared with the reference compound. |
| PubMedSearch : Zhou_2008_Bioorg.Med.Chem_16_8011 |
| PubMedID: 18701305 |
Zhou X, Wang XB, Wang T, Kong LY (2008)
Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues
Bioorganic & Medicinal Chemistry
16 :8011
Zhou X, Wang XB, Wang T, Kong LY (2008)
Bioorganic & Medicinal Chemistry
16 :8011