| Title : The receptor binding domain of MERS-CoV: the dawn of vaccine and treatment development - Zhou_2014_J.Formos.Med.Assoc_113_143 |
| Author(s) : Zhou N , Zhang Y , Zhang JC , Feng L , Bao JK |
| Ref : J Formos Med Assoc , 113 :143 , 2014 |
|
Abstract :
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another "SARS-like" threat to the world. It has an extremely high death rate ( approximately 50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs. |
| PubMedSearch : Zhou_2014_J.Formos.Med.Assoc_113_143 |
| PubMedID: 24342026 |
Zhou N, Zhang Y, Zhang JC, Feng L, Bao JK (2014)
The receptor binding domain of MERS-CoV: the dawn of vaccine and treatment development
J Formos Med Assoc
113 :143
Zhou N, Zhang Y, Zhang JC, Feng L, Bao JK (2014)
J Formos Med Assoc
113 :143