| Title : New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus - Zhou_2018_Fitoterapia_130_26 |
| Author(s) : Zhou QY , Yang XQ , Zhang ZX , Wang BY , Hu M , Yang YB , Zhou H , Ding ZT |
| Ref : Fitoterapia , 130 :26 , 2018 |
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Abstract :
Five new metabolites belonging to two backbones of pulvilloric acid-type azaphilone and tremulane sesquiterpene were obtained and their structures were determined by spectral analysis. Based on the biogenesis analysis, tremulane sesquiterpenes were obtained from Irpex lacteus by the stimulation of mixed-culture. The antifungal selectivities of metabolites produced by fungus against their co-culture fungus and common pathogens, exhibited competitive interaction of this mix-culture. The tremulane sesquiterpene conocenol B produced by I. lacteus through the induction of Nigrospora oryzae showed selectivity of anti-fungal activity against its co-culture fungus, N. oryzae, with MICs at 16 mug/mL and 128 mug/mL against I. lacteus. The fungus can metabolize these new compounds to inhibit the growth of co-culture fungus while not inhibiting its own growth. Compound 5 was active against acetylcholinesterase (AChE) with a ratio of 35% at the concentration of 50 muM. |
| PubMedSearch : Zhou_2018_Fitoterapia_130_26 |
| PubMedID: 30076888 |
Zhou QY, Yang XQ, Zhang ZX, Wang BY, Hu M, Yang YB, Zhou H, Ding ZT (2018)
New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus
Fitoterapia
130 :26
Zhou QY, Yang XQ, Zhang ZX, Wang BY, Hu M, Yang YB, Zhou H, Ding ZT (2018)
Fitoterapia
130 :26