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Zhu_2005_Asian.J.Androl_7_245

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Title : Expression of a novel dipeptidyl peptidase 8 (DPP8) transcript variant, DPP8-v3, in human testis - Zhu_2005_Asian.J.Androl_7_245
Author(s) : Zhu H , Zhou ZM , Lu L , Xu M , Wang H , Li JM , Sha JH
Ref : Asian J Androl , 7 :245 , 2005
Abstract :

AIM: To investigate the role of a novel dipeptidyl peptidase 8 transcript variant (DPP8-v3) gene in testis development and/or spermatogenesis.
METHODS: A human testis cDNA microarray was hybridized with mRNA of human adult and fetal testes. Differentially expressed clones were sequenced and characterized and their expression was analyzed by real-time reverse transcription polymerase chain reaction (RT-PCR) and Southern-blot analysis.
RESULTS: A new transcript variant of the human dipeptidyl peptidase (DPP8), exhibiting a 5-fold higher expression level in human adult than that in fetal testes, was cloned and was named DPP8 variant 3 (DPP8-v3). The full-length sequence of DPP8-v3 was 3,030 bp, encoding a protein of 898 amino acids. CONCLUSION: DPP8-v3 is a novel human DPP8 transcript variant highly expressed in the adult testis. Similar to DPPIV, DPP8-v3 may play a key role in the immunoregulation of testes and accordingly may influence spermatogenesis and male fertility.
PubMedSearch : Zhu_2005_Asian.J.Androl_7_245
PubMedID: 16110352

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Citations formats

Zhu H, Zhou ZM, Lu L, Xu M, Wang H, Li JM, Sha JH (2005)
Expression of a novel dipeptidyl peptidase 8 (DPP8) transcript variant, DPP8-v3, in human testis
Asian J Androl 7 :245

Zhu H, Zhou ZM, Lu L, Xu M, Wang H, Li JM, Sha JH (2005)
Asian J Androl 7 :245