Zhu_2013_Evid.Based.Complement.Alternat.Med_2013_731385

Reference

Title : Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes - Zhu_2013_Evid.Based.Complement.Alternat.Med_2013_731385
Author(s) : Zhu KY , Xu SL , Choi RC , Yan AL , Dong TTX , Tsim KWK
Ref : Evid Based Complement Alternat Med , 2013 :731385 , 2013
Abstract :

Kai-xin-san (KXS), a Chinese herbal decoction prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria. In China, KXS has been used to treat stress-related psychiatric diseases with the symptoms of depression and forgetfulness. Although animal study has supported the antidepression function of KXS, the mechanism in cellular level is still unknown. Here, a chemically standardized water extract of KXS was applied onto cultured astrocytes in exploring the action mechanisms of KXS treatment, which significantly stimulated the expression and secretion of neurotrophic factors, including NGF, BDNF, and GDNF, in a dose-dependent manner: the stimulation was both in mRNA and protein levels. In addition, the water extracts of four individual herbs did not significantly stimulate the expression of neurotrophic factors, which could explain the optimized effect of KXS in a herbal decoction. The KXS-induced expression of neurotrophic factors did not depend on signaling mediated by estrogen receptor or protein kinase. The results suggested that the antidepressant-like action of KXS might be mediated by an increase of expression of neurotrophic factors in astrocytes, which fully supported the clinical usage of this decoction.

PubMedSearch : Zhu_2013_Evid.Based.Complement.Alternat.Med_2013_731385
PubMedID: 24222781

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Citations formats

Zhu KY, Xu SL, Choi RC, Yan AL, Dong TTX, Tsim KWK (2013)
Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes
Evid Based Complement Alternat Med 2013 :731385

Zhu KY, Xu SL, Choi RC, Yan AL, Dong TTX, Tsim KWK (2013)
Evid Based Complement Alternat Med 2013 :731385