Title : Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth - Zhu_2014_Int.J.Environ.Res.Public.Health_11_4544 |
Author(s) : Zhu XC , Lin J , Wang Q , Liu H , Qiu L , Fang DZ |
Ref : Int J Environ Research Public Health , 11 :4544 , 2014 |
Abstract :
To investigate the effects of a high-carbohydrate and low-fat (HC/LF) diet on plasma lipids and apolipoproteins (Apos) of healthy Chinese Han youth with different genotypes of lipoprotein lipase gene (LPL) rs326, 56 subjects were given a washout diet of 30.1% fat and 54.1% carbohydrate for seven days, followed by the HC/LF diet of 13.8% fat and 70.1% carbohydrate for six days, with no total energy restriction. Plasma glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Apo B-100 and Apo A-I were analyzed at baseline and before and after the HC/LF diet. The results show that, when compared with before the HC/LF diet, only the male G carriers experienced increased HDL-C (p = 0.008) and Apo A-I (p = 0.005) after the HC/LF diet. Decreased TC in both males and females and increased TG in females were found regardless of the genotype after the HC/LF diet. LDL-C decreased in all the subjects although the decrease was not significant in the female G carriers. These results demonstrate that the G allele of LPL rs326 associates with the elevated levels of HDL-C and Apo A-I after the HC/LF diet in males of the healthy Chinese Han Youth. |
PubMedSearch : Zhu_2014_Int.J.Environ.Res.Public.Health_11_4544 |
PubMedID: 24762672 |
Zhu XC, Lin J, Wang Q, Liu H, Qiu L, Fang DZ (2014)
Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth
Int J Environ Research Public Health
11 :4544
Zhu XC, Lin J, Wang Q, Liu H, Qiu L, Fang DZ (2014)
Int J Environ Research Public Health
11 :4544