| Title : Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities - Zhu_2015_Arch.Pharm.Res_38_604 |
| Author(s) : Zhu YY , Li X , Yu HY , Xiong YF , Zhang P , Pi HF , Ruan HL |
| Ref : Arch Pharm Res , 38 :604 , 2015 |
|
Abstract :
Three novel alkaloids (1-3), together with nineteen known ones (4-22), were isolated from the bulbs of Lycoris longituba. Their structures were elucidated on the basis of extensive spectroscopic analyses, which belong to several Amaryllidaceae alkaloid skeletons. Among them, the harmane-type alkaloids (the new compound 1 and the known compounds 5, 6 and 7) were found for the first time from Lycoris genus. The isolates were tested for their neuroprotective activities against CoCl2, H2O2 and Abeta25-35-induced SH-SY5Y cell injuries, and the majority of them exhibited neuroprotective activities of different degrees. The acetylcholinesterase (AChE) inhibitory activities of the isolated alkaloids were also evaluated, while compounds 12, 14-20 and 22 exhibited extremely significant AChE inhibitory activities. |
| PubMedSearch : Zhu_2015_Arch.Pharm.Res_38_604 |
| PubMedID: 25219454 |
Zhu YY, Li X, Yu HY, Xiong YF, Zhang P, Pi HF, Ruan HL (2015)
Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities
Arch Pharm Res
38 :604
Zhu YY, Li X, Yu HY, Xiong YF, Zhang P, Pi HF, Ruan HL (2015)
Arch Pharm Res
38 :604