| Title : Guided isolation of secondary metabolites from Nectria sp. MHHJ-3 by molecular network strategy - Zhu_2023_Fitoterapia__105668 |
| Author(s) : Zhu L , Gan D , Dong SH , He BJ , Li CZ , Wang CY , Cai L , Su JW , Ding ZT |
| Ref : Fitoterapia , :105668 , 2023 |
|
Abstract :
The fungus Nectria sp. MHHJ-3 was isolated from Illigera rhodantha. A molecular networking-guided the secondary metabolites investigation of Nectria sp. MHHJ-3 led to the isolation of ten metabolites (1-10), including two new naphthalenone derivatives, nectrianaphthalenones A (1) and B (2), and two new steroids, nectriasteroids A (3) and B (4). Their structures were elucidated by extensive spectroscopic analysis including the HRESIMS, 1D/2D NMR and electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway for 1-2 was proposed. Compounds 1 and 2 exhibited moderate acetylcholinesterase (AChE) inhibitory activities. Compounds 3 and 4 showed significant cytotoxic activity against selected tumor cells. Particularly, compound 3 exhibited the strongest activity against A549 cells with an IC(50) value of 13.73 +/- 0.03 microM, which was at the same grade with that of positive control cisplatin. |
| PubMedSearch : Zhu_2023_Fitoterapia__105668 |
| PubMedID: 37683876 |
Zhu L, Gan D, Dong SH, He BJ, Li CZ, Wang CY, Cai L, Su JW, Ding ZT (2023)
Guided isolation of secondary metabolites from Nectria sp. MHHJ-3 by molecular network strategy
Fitoterapia
:105668
Zhu L, Gan D, Dong SH, He BJ, Li CZ, Wang CY, Cai L, Su JW, Ding ZT (2023)
Fitoterapia
:105668