Zieniuk_2022_Molecules_27_

Reference

Title : Lipase-Catalyzed Synthesis, Antioxidant Activity, Antimicrobial Properties and Molecular Docking Studies of Butyl Dihydrocaffeate - Zieniuk_2022_Molecules_27_
Author(s) : Zieniuk B , Ononamadu CJ , Jasinska K , Wierzchowska K , Fabiszewska A
Ref : Molecules , 27 : , 2022
Abstract :

Green chemistry approaches, such as lipase-catalyzed esterification, are promising methods for obtaining valuable chemical compounds. In the case of the use of lipases, unlike in aqueous environments, the processes of the ester bond formations are encountered in organic solvents. The aim of the current research was to carry out the lipase-catalyzed synthesis of an ester of dihydrocaffeic acid. The synthesized compound was then evaluated for antioxidant and antimicrobial activities. However, the vast majority of its antioxidant activity was retained, which was demonstrated by means of DPPH. (2,2-diphenyl-1-picrylhydrazyl) and CUPRAC (cupric ion reducing antioxidant capacity) methods. Regarding its antimicrobial properties, the antifungal activity against Rhizopus oryzae is worth mentioning. The minimum inhibitory and fungicidal concentrations were 1 and 2 mM, respectively. The high antifungal activity prompted the use of molecular docking studies to verify potential protein targets for butyl ester of dihydrocaffeic ester. In the case of one fungal protein, namely 14-alpha sterol demethylase B, it was observed that the ester had comparable binding energy to the triazole medication, isavuconazole, but the interacted amino acid residues were different.

PubMedSearch : Zieniuk_2022_Molecules_27_
PubMedID: 35956977

Related information

Citations formats

Zieniuk B, Ononamadu CJ, Jasinska K, Wierzchowska K, Fabiszewska A (2022)
Lipase-Catalyzed Synthesis, Antioxidant Activity, Antimicrobial Properties and Molecular Docking Studies of Butyl Dihydrocaffeate
Molecules 27 :

Zieniuk B, Ononamadu CJ, Jasinska K, Wierzchowska K, Fabiszewska A (2022)
Molecules 27 :