Zuo_2015_Wei.Sheng.Yan.Jiu_44_943

OBJECTIVE: To study the effects of lingonberry extraction on mice cognitive impairment caused by chronic stress.
METHODS: Kunming mice were randomly divided into six groups, which were control group, stress model group, the fluoxetine group (dose of 4.4 mg . kg(-1) . d(-1)), lingonberry extraction low, medium and high dose group (respectively 50, 100 and 200 mg . kg(-1) . d(-1)). All groups were given chronic uncertainty stress but the control group, and were intragastric administration for 18 days. Then the cognition of the mice was tested by using water maze, the contents of the SOD, GSH-Px, MDA and the activity of the neurotransmitters such as noradreline (NE), serotonin (5-HT), glucocorticoids (GC), acetylcholinesterase (AchE) were measured by using kit.
RESULTS: Lingonberry extraction improved the cognition and memory of the mice induced by chronic uncertainty stress, increased the content of the SOD and GSH-Px in mice brain, and decreased the content of oxidative damage markers MDA. Lingonberry extraction could also inhibit the increase of GC, inhibit the activity of AchE in blood serum, elevated the content of 5-HT and NE in mice blood serum and brain. CONCLUSION: Lingonberry extraction improved the cognition and memory of the mice induced by chronic uncertainty stress. The possible mechanism was that lingonberry enhanced the antioxidative ability of tissue and improved the disorder of neurotransmitter levels caused by chronic stress.