al Fahad_2014_Angew.Chem.Int.Ed.Engl_53_7519

Reference

Title : The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid - al Fahad_2014_Angew.Chem.Int.Ed.Engl_53_7519
Author(s) : al Fahad A , Abood A , Simpson TJ , Cox RJ
Ref : Angew Chem Int Ed Engl , 53 :7519 , 2014
Abstract :

A series of directed knockout experiments, combined with an invitro assay of pathway components, has elucidated for the first time the chemical steps involved in the biosynthesis of the tropolone class of fungal maleic anhydrides. The pathway involves the stepwise oxidation of aldehyde and methyl carbon atoms to form a 1,2-dicarboxylate. A hydrolase-catalyzed interconversion of this and the corresponding maleic anhydride, followed by decarboxylation of the diacid leads to the pathway's final product of stipitatic acid.

PubMedSearch : al Fahad_2014_Angew.Chem.Int.Ed.Engl_53_7519
PubMedID: 24863423
Gene_locus related to this paper: talsn-tropf , talsn-tropi

Related information

Gene_locus talsn-tropf    talsn-tropi

Citations formats

al Fahad A, Abood A, Simpson TJ, Cox RJ (2014)
The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid
Angew Chem Int Ed Engl 53 :7519

al Fahad A, Abood A, Simpson TJ, Cox RJ (2014)
Angew Chem Int Ed Engl 53 :7519