Title : Cholinesterase Inhibitors Modulate Autonomic Function in Patients with Alzheimer s Disease and Mixed Dementia - da Costa Dias_2013_Curr.Alzheimer.Res_10_476 |
Author(s) : da Costa Dias FL , Ferreira Lisboa da Silva RM , de Moraes EN , Caramelli P |
Ref : Curr Alzheimer Res , 10 :476 , 2013 |
Abstract :
Cholinesterase inhibitors (ChEIs), the mainstay treatment for dementia, have systemic actions that can affect cardiovascular and autonomic nervous system (ANS). Thirty-nine patients with Alzheimer s disease or mixed dementia underwent a comprehensive clinical evaluation, prior to and during ChEIs therapy, including orthostatic challenge, electrocardiogram (EKG) and heart rate variability (HRV) spectral analysis through Holter recordings. ChEIs therapy determined a decrease in supine diastolic blood pressure (BP) and in both diastolic and systolic BP in orthostatic position (79.8 +/- 9.0 vs. 76.4 +/- 9.3 mmHg, p=0.012; 79.9 +/- 11.6 vs. 75.3 +/- 9.9, p=0.005 and 144.6 +/- 25.8 vs. 137.6 +/- 21.1, p=0.020, respectively). Spectral analysis revealed no difference on static HRV components, but, during orthostatic challenge, an increase in LF/HF ratio (2.2+/-2.4 vs. 4.6+/-5.9, p=0.011) and a reduction in HF component emerged (1604.3 +/- 5610.1 vs. 266.1 +/- 525.5, p=0.010). ChEIs showed no influence on EKG parameters or on the occurrence of orthostatic hypotension. Treatment with ChEIs was associated with functional improvement of the ANS behavior and to a decrease in supine DBP and in both orthostatic SBP and DBP. |
PubMedSearch : da Costa Dias_2013_Curr.Alzheimer.Res_10_476 |
PubMedID: 23627707 |
da Costa Dias FL, Ferreira Lisboa da Silva RM, de Moraes EN, Caramelli P (2013)
Cholinesterase Inhibitors Modulate Autonomic Function in Patients with Alzheimer s Disease and Mixed Dementia
Curr Alzheimer Res
10 :476
da Costa Dias FL, Ferreira Lisboa da Silva RM, de Moraes EN, Caramelli P (2013)
Curr Alzheimer Res
10 :476