| Title : Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation - da Silva_2001_Bioorg.Med.Chem.Lett_11_283 |
| Author(s) : da Silva AJM , Melo PA , Silva NM , Brito FV , Buarque CD , de Souza DV , Rodrigues VP , Pocas ES , Noel F , Albuquerque EX , Costa PR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :283 , 2001 |
|
Abstract :
Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 microM) was selected for study of its pharmacological profile. |
| PubMedSearch : da Silva_2001_Bioorg.Med.Chem.Lett_11_283 |
| PubMedID: 11212092 |
da Silva AJM, Melo PA, Silva NM, Brito FV, Buarque CD, de Souza DV, Rodrigues VP, Pocas ES, Noel F, Albuquerque EX, Costa PR (2001)
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
Bioorganic & Medicinal Chemistry Lett
11 :283
da Silva AJM, Melo PA, Silva NM, Brito FV, Buarque CD, de Souza DV, Rodrigues VP, Pocas ES, Noel F, Albuquerque EX, Costa PR (2001)
Bioorganic & Medicinal Chemistry Lett
11 :283