da Silva_2020_Neurotox.Res_37_893

Reference

Title : Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities - da Silva_2020_Neurotox.Res_37_893
Author(s) : da Silva WMB , de Oliveira Pinheiro S , Alves DR , de Menezes J , Magalhaes FEA , Silva FCO , Silva J , Marinho ES , De Morais SM
Ref : Neurotox Res , 37 :893 , 2020
Abstract :

The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin coordination complexes with the metal ions Cu(+2), Zn(+2), Ni(+2), Co(+2), and Fe(+2) were synthesized to investigate their potential use against Alzheimer's disease, by evaluating the inhibition of acetylcholinesterase in vitro and in silico, as well as the antioxidant activity, toxicity, and anxiolytic action in the zebrafish (Danio rerio) model. The organic complexes were characterized by UV-Vis and FT-IR. The spectral information suggested that coordination of metals occurs with the carbonyl group and OH linked to the C-3 carbon of quercetin. The quercetin-Fe (QFe) complex presented the best antioxidant and antiacetylcholinesterase actions, and these results were confirmed by molecular docking. In the toxicity and locomotor evaluation, the quercetin molecules and the synthesized complexes, mainly QCu and QZn derivatives, showed the highest degree of inhibition of the fish's locomotor activity, suggesting a possible anxiolytic action. Then, quercetin complexes with metals, mainly with Fe(+2), represent valuable compounds and deserve more investigation as promising agents against Alzheimer's disease.

PubMedSearch : da Silva_2020_Neurotox.Res_37_893
PubMedID: 31853730

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Citations formats

da Silva WMB, de Oliveira Pinheiro S, Alves DR, de Menezes J, Magalhaes FEA, Silva FCO, Silva J, Marinho ES, De Morais SM (2020)
Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities
Neurotox Res 37 :893

da Silva WMB, de Oliveira Pinheiro S, Alves DR, de Menezes J, Magalhaes FEA, Silva FCO, Silva J, Marinho ES, De Morais SM (2020)
Neurotox Res 37 :893