| Title : Entorhinal cortex long-term potentiation evoked by theta-patterned stimulation of associative fibers in the isolated in vitro guinea pig brain - de Curtis_1993_Brain.Res_600_327 |
| Author(s) : de Curtis M , Llinas RR |
| Ref : Brain Research , 600 :327 , 1993 |
|
Abstract :
Long-term potentiation (LTP) induced in the lateral entorhinal cortex by theta-patterned tetanic stimulation of the piriform cortex was analyzed in the isolated guinea pig brain maintained in vitro. Monosynaptic excitatory postsynaptic potentials (EPSPs) evoked by stimulation of the piriform cortex are composed of an early and late component selectively blocked by non-N-methyl-D-aspartate (non-NMDA) and NMDA receptor antagonists, respectively. LTP induction was dependent on NMDA receptor activation, being blocked by perfusing the preparation with 2-amino-5-phosphonovalerate (AP-5). LTP was expressed through synaptic enhancement of both early non-NMDA and late, possibly NMDA receptor-mediated responses. |
| PubMedSearch : de Curtis_1993_Brain.Res_600_327 |
| PubMedID: 8094643 |
de Curtis M, Llinas RR (1993)
Entorhinal cortex long-term potentiation evoked by theta-patterned stimulation of associative fibers in the isolated in vitro guinea pig brain
Brain Research
600 :327
de Curtis M, Llinas RR (1993)
Brain Research
600 :327