| Title : Carbazates as potent inhibitors of hormone-sensitive lipase - de Jong_2004_Bioorg.Med.Chem.Lett_14_1741 |
| Author(s) : de Jong JC , Sorensen LG , Tornqvist H , Jacobsen P |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :1741 , 2004 |
|
Abstract :
The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4-tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency. |
| PubMedSearch : de Jong_2004_Bioorg.Med.Chem.Lett_14_1741 |
| PubMedID: 15026062 |
| Inhibitor | CHEMBL49895 |
de Jong JC, Sorensen LG, Tornqvist H, Jacobsen P (2004)
Carbazates as potent inhibitors of hormone-sensitive lipase
Bioorganic & Medicinal Chemistry Lett
14 :1741
de Jong JC, Sorensen LG, Tornqvist H, Jacobsen P (2004)
Bioorganic & Medicinal Chemistry Lett
14 :1741